Photo taken from Erman Akkus/X
Dec 29, 2023, 16:34
Erman Akkus: KEYNOTE-585 – although pathological complete response improved, no survival advantage
Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:
“KEYNOTE-585: Neoadjuvant and adjuvant pembro+chemo in locally advanced gastric/GE cancer in The Lancet Oncology.
- 804 patients
- 3xPembro/placebo+chemo >surgery > 3xPembro/placebo+chemo > 11pembro/placebo
- pCR: 12.9% vs 2%, p<0.00001
- Median event free survival: 44.4 mo vs 25.3 mo (HR: 0.81, p=0.01)
- Median OS: 60.7 mo vs 58 mo, p=0.17
Although pathological complete response improved, no survival advantage.”
Source: Erman Akkus/X