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Anirban Maitra: Persistence of “epigenetic memory” following an ADM transition state
Mar 31, 2025, 12:00

Anirban Maitra: Persistence of “epigenetic memory” following an ADM transition state

Anirban Maitra, Scientific Director of the Sheikh Ahmed Pancreatic Cancer Research Center, shared a post on X:

Andy Feinberg has an interesting study profiling the epigenetics and transcriptomics of acinar ducal metaplasia (ADM) in a KLF4-driven model, sans KRAS mutation.

The study shows persistence of “epigenetic memory” following an ADM transition state.”

“DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation.”

Authors: Emily K.W. Lo, Adrian Idrizi, Rakel Tryggvadottir, Weiqiang Zhou, Wenpin Hou, Hongkai Ji, Patrick Cahan, Andrew P. Feinberg

Anirban Maitra: Persistence of "epigenetic memory" following an ADM transition state