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Nirogacestat shows lasting benefits for desmoid tumors – ESMO
Mar 20, 2025, 08:31

Nirogacestat shows lasting benefits for desmoid tumors – ESMO

ESMO (European Society for Medical Oncology) shared a post on LinkedIn:

“In an updated analysis presented at ESMO Rare Cancers25, nirogacestat increased the objective response rate from 34.3% (for up to 1 year of treatment) to 45.7% (for up to 4 years of treatment) in patients with progressing Desmoid Tumours in the DeFi trial.

The incidence and severity of adverse events decreased after year 1. Real-world findings with nirogacestat were also presented from the DeNi study, which may help delineate which patients benefit most from treatment.

More results in the ESMO Daily Reporter.”

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