January, 2025
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Krish Patel: Multi-center effort of CD19 allo iPSC CAR-NK in B-cell lymphomas
Jan 12, 2025, 15:23

Krish Patel: Multi-center effort of CD19 allo iPSC CAR-NK in B-cell lymphomas

Krish Patel, Director of the Lymphoma Research Program at the Sarah Cannon Research Institute, shared on LinkedIn:

“Long awaited…

Excited to see in press our multi-center effort of CD19 allo iPSC CAR-NK (FT596) in B-cell lymphomas!

Important proof of concepts and signals from this study:

-very low CRS.
-no ICANS.
-multi dose off shelf treatment.
-durable responses in challenging histologies.

Lots still to do to advance the field of allo CAR-NK: we need further improved response rates, optizimation of dosing and lymphodepletion approaches, but this is a good place to move forward from.

I am optimistic that our field will continue to make advancements here!”

Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial.

Authors: Armin Ghobadi, Veronika Bachanova, Krish Patel, Jae H Park, Ian Flinn, Peter A Riedell, Carlos Bachier, Catherine S Diefenbach, Carol Wong, Cara Bickers, Lilly Wong, Deepa Patel, Jode Goodridge, Matthew Denholt, Bahram Valamehr, Rebecca L Elstrom, Paolo Strati

Krish Patel