E. Shyam P. Reddy: Aging brings two opposing trends in cancer risk
E. Shyam P. Reddy, Professor and Director of Cancer Biology Program in Department of OB/GYN at Morehouse School of Medicine, shared a post on LinkedIn:
“Aging brings two opposing trends in cancer risk: first, the risk climbs in our 60s and 70s, as decades of genetic mutations build up in our bodies. But then, past the age of around 80, the risk drops again – and a new study may explain a key reason why.
The international team of scientists behind the study analyzed lung cancer in mice, tracking the behavior of alveolar type 2 (AT2) stem cells. These cells are crucial for lung regeneration, and are also where many lung cancers get started.
What emerged was higher levels of a protein called NUPR1 in the older mice. This caused cells to act as if they were deficient in iron, which in turn limited their regeneration rates – putting restrictions on both healthy growth and cancerous tumors.
Cancer cell study:
Both mouse and human cells were included in the research. (Memorial Sloan Kettering Cancer Center)
“The aging cells actually have more iron, but for reasons we don’t yet fully understand, they function like they don’t have enough,” says cancer biologist Xueqian Zhuang, from the Memorial Sloan Kettering Cancer Center (MSK) in New York.”
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