Xiaolei Liu: New insights into lymphatic development by CXCL12/CXCR4 signaling
Xiaolei Liu, Assistant Professor in the Lemole Center for Integrated Lymphatics Research at Temple University, posted the following on X:
“I am very happy to share that the first research article from the Liu lab entitled ‘A neuro-lymphatic communication guides lymphatic development by CXCL12/CXCR4 signaling’ is officially accepted by Development! More threads for the findings of the paper!
Thread 1: in this manuscript, we analyzed a main chemokine receptor CXCR4 in lymphatic development using LEC-specific CXCR4 KO mice. we found that those mutant embryos displayed severe edema with major lymphatic defects including reduced sprouting, migration and branching.
T2: We found very interestingly, in the mutant lymphatic vessels, VEGFR3 was mis-localized such that it does not reside on the surface of the LECs. We then questioned whether CXCR4 is required for VEGFC mediated VEGFR3 signaling.
T3: our in vitro data support that CXCR4 is required for VEGFR3 surface expression and VEGFC mediated VEGFR3/PI3K/AKT signaling as well as LEC migration and sprouting in vitro.
T4: Inspired by many questions while we talked about our story, where is the ligand from? we used CXCL12 reported mice and revealed something REALLY cool! There is a neuro-lymphatic communications guiding lymphatic development.
T5: Excitingly, CXCL12 mutant embryos phenocopies the lymphatic defects seen in CXCR4 mutant embryos.
”
A neuro-lymphatic communication guides lymphatic development by CXCL12/CXCR4 signaling
Authors: Long Nguyen Hoang Do, Esteban Delgado, Casey G. Lim, Meriem Bkhache, Amanda M. Peluzzo, Yiming Hua, Manisha Oza, Sadia Mohsin, Hong Chen, Michael V. Autieri, Seonhee Kim, Xiaolei Liu.
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