New research findings reveal biological differences in sarcomas – The Institute of Cancer Research

The Institute of Cancer Research shared the following on LinkedIn:

“A study led by Dr. Paul Huang at the ICR has found that distinct biological differences may be the reason why survival outcomes for young people with sarcomas have lagged behind those of children and older adults.

Through their research, which used data from more than 300 people with soft tissue tumours, the scientists showed that the protein profiles of adolescent and young adult (AYA) patients are different from those of patients belonging to other age groups.

The abundance of five key proteins was found to be significant even once the results were adjusted to account for other variables, such as tumour size. These differences could affect how sarcomas respond to treatment, thereby determining patients’ likelihood of survival.

The team also identified a possible biomarker that could help predict which AYA patients are most likely to have aggressive forms of sarcoma that will require more intensive treatment. Meanwhile, individuals without this biomarker could potentially be spared from the side effects of over treatment.

Read more about this work here.”

Source: The Institute of Cancer Research/LinkedIn