Neuroblastoma study identifies mechanisms affecting resistance to chemotherapy – NCI Center for Cancer Research

NCI Center for Cancer Research posted the following on LinkedIn:

“NEW FINDINGS: Neuroblastoma consists primarily of two interconverting subtypes: adrenergic and mesenchymal. This study, which comes from the laboratory of Carol J. Thiele, Ph.D., identifies mechanisms that facilitate lineage plasticity, which may affect resistance to chemotherapy.

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Dr. Thiele is the Deputy Chief of the Pediatric Oncology Branch. Her team’s ongoing studies are aimed at understanding epigenetic/chromatin-based mechanisms to re-program and differentiate neuroblastoma tumor cells.”

Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity

Authors: Man Xu, Jason J Hong, Xiyuan Zhang, Ming Sun, Xingyu Liu, Jeeyoun Kang, Hannah Stack, Wendy Fang, Haiyan Lei, Xavier Lacoste, Reona Okada, Raina Jung, Rosa Nguyen, Jack F Shern, Carol J Thiele, and Zhihui Liu.

Source: NCI Center for Cancer Research/LinkedIn