Mark Lewis: From the first day of fellowship I was taught to “respect oxaliplatin”

Mark Lewis reshared a post on X by Erman Akkus, Medical Oncology Fellow at Ankara University, adding: 

“From my very first day of fellowship I was taught to “respect oxaliplatin” That drug is nothing to trifle with, especially concerning the risk of irreversible neuropathy Kudos to the investigators for enhancing our understanding of GI and geriatric oncology.”

Quoting Erman Akkus’s post:

“FOLFOX/Xelox + beva vs. 5FU/cape +beva in first line treatment of metastatic CRC in older patients at Journal of Clinical Oncology.

Median age 80 and 79

• No difference in PFS, 10 vs 9.4 mo.
• No difference in OS, 19.7 vs 21.3 mo.
• grade ≥3 AEs 69% vs. 52%.

~65% left sided and ~36% RAS WT.”

Oxaliplatin Added to Fluoropyrimidine/Bevacizumab as Initial Therapy for Unresectable Metastatic Colorectal Cancer in Older Patients: A Multicenter, Randomized, Open-Label Phase III Trial (JCOG1018)

Authors: Atsuo Takashima, Tetsuya Hamaguchi, Junki Mizusawa, Fumio Nagashima, Masahiko Ando, Hitoshi Ojima, Tadamichi Denda, Jun Watanabe, Katsunori Shinozaki, Hideo Baba, Masako Asayama, Seiji Hasegawa, Toshiki Masuishi, Ken Nakata, Shunsuke Tsukamoto, Hiroshi Katayama, Kenichi Nakamura, Haruhiko Fukuda, Yukihide Kanemitsu, and Yasuhiro Shimada.

Source: Mark Lewis/X and Erman Akkus/X

Mark A. Lewis is the Director of Gastrointestinal Oncology at Intermountain Healthcare in Utah, the Co-Chair of adolescent and young adult (AYA) oncology in the SWOG cooperative group, and the Vice President of American Multiple Endocrine Neoplasia Support. Dr. Lewis is also a well-known patient advocate and social media influencer. His interests are neuroendocrine tumors and cancer syndromes.

Erman Akkus is a medical oncology fellow at the Ankara University, Faculty of Medicine. Previously, he was an Internal Medicine Resident at the Ankara University, Faculty of Medicine. He was also a Visiting Researcher at the University of Oslo. He completed his education from the Medical University of Vienna.