Photo from Erman Akkus/X
Aug 27, 2024, 22:10
Erman Akkus: Genome targeted cancer therapies in NCCN guidelines according to the ESMO MCBS and ESCAT
Erman Akkus, Medical Oncology Fellow at Ankara University Faculty of Medicine, shared a post on X:
“Genome targeted cancer therapies in National Comprehensive Cancer Network (NCCN) guidelines according to the ESMO MCBS and ESCAT.
411 recommendations:
- 16% relied on only case reports or pre-clinical studies
- 78% of clinical trials are phase I/II
- 76% of clinical trials are single arm
- In 78%, primary endpoint is ORR
- 60% is ESCAT tier 1
- Only 12% showed substantial clinical benefit (ESMO-MCBS grades 4-5).”
Source: Erman Akkus/X
Authors: Ariadna Tibau, Thomas J Hwang, Jerry Avorn, and Aaron S Kesselheim.
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