The Breast Cancer Research Foundation (BCRF) shared on LinkedIn:
“While most breast cancers aren’t caused by inherited genetic mutations, some people have an increased risk due to inherited genetic factors – and that risk can be more complex than you might think.
BRCA1 and BRCA2 are among the best-known genes linked to breast cancer risk, but researchers are studying many others, as well as how multiple genetic factors can work together to influence risk.
From genetic risk assessment to screening, prevention and targeted treatments, research is helping us better understand hereditary breast cancer and what that could mean for the future.
Learn more about hereditary breast cancer and the research underway to better understand genetic risk.
5 Things to Know About Hereditary Breast Cancer
1. Most breast cancers aren’t hereditary.
Most breast cancers are not caused by inherited genetic mutations. However, some people have a higher risk because of their family history and inherited genetic factors.
2. BRCA1 & BRCA2 aren’t the only genes that matter.
BRCA1 and BRCA2 are the best-known genes associated with increased breast cancer risk. Researchers have also identified other genes, including PALB2, BARD1, TP53, and ATM, that can influence risk.
3. You don’t need a family history to have an inherited mutation.
Some people with BRCA1, BRCA2, or other inherited mutations don’t have a known family history of breast cancer.
4. Genetic risk is more complex than one gene.
Researchers are studying how multiple genetic factors can work together to influence breast cancer risk—including through polygenic risk scores, which look at the combined effects of many genetic variants.
5. Research is changing what’s possible.
BCRF researchers are working to improve risk assessment, screening, prevention, and targeted treatments for people with inherited breast cancer risk.”
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