Photo of Toni Choueiri from X
Jun 6, 2024, 04:56
Zach Klaassen: Biomarker analyses in aRCC from Ph 3 CLEAR trial by Toni Choueiri
Zach Klaassen, Urology Oncologist at Georgia Cancer Center, shared a post on X:
“Biomarker analyses in aRCC from Ph 3 CLEAR trial at ASCO24 by Toni Choueiri:
- Len + Pembro arm:
– Continuous GEP sig score not associated with the best resp
– MYC sig score: -ve associated with the best resp
– ORR MYC-high vs -low: 66.3% vs 84.0% - Sun arm:
– GEP sig score assoc with the best resp (p = 0.010)
– ORR GEP-high vs -low: 46.9% vs 28.8%
– Angiogenesis-high vs -low: 52.1% vs 30.4% - ORR/PFS: with Len + Pembro vs Sun, regardless of deleterious mutation status of BAP1, VHL, PBRM1, SETD2, KDM5C.”
Source: Zach Klaassen/X
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