Pashtoon Kasi, Medical Director of GI Medical Oncology at City of Hope Orange County, shared on X:
“What NEST taught us?
Lesson 3: Pattern of response.
Immunotherapy response ≠ chemo or radiation response. We called it ‘inside-out’- a serosa-to-mucosa pattern of response. Likely elimination of micrometastatic disease translating into higher DFS/cures?”
Title: Neoadjuvant Botensilimab/Balstilimab for localized mismatch repair proficient and deficient colon cancer: Results of the NEST phase 2 clinical trial
Authors: Manish Shah, Erika Hissong, Mehraneh Jafari, Pashtoon Murtaza Kasi, Maider Astorkia, Sahrish Khan, Casey Owens, Zhengming Chen, Heather Yeo, Fabio Socciarelli, Sandipto Sarkar, Alana Nguyen, Despina Siolas, Allyson Ocean, Kelly Garrett, Lea Lowenfeld, Alessio Pigazzi, Preethi Guniganti, Sanjay Patel, Doron Betel, Manuel Hidalgo.

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Pashtoon Kasi was recognized among OncoDaily’s ‘Top 100 Xfluencers in Colorectal Cancer: Key Opinion Leaders to follow on X (Twitter) in 2024‘, highlighting their contributions to the field of oncology.
Nominations for ‘100 Influential People in Oncology 2026’ are now open, recognizing leaders, researchers, clinicians, innovators, advocates, and other individuals making a meaningful impact on oncology and cancer care.
Don’t miss the opportunity to nominate yourself, a colleague, or someone whose contributions deserve to be recognized.
Submit Your Nomination by September 15.
