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Luke Yun: Breakthrough in the Hidden Biology of Fusion Oncoproteins with AI
Luke (Jeongwook) Yun/LinkedIn
Feb 28, 2025, 14:14

Luke Yun: Breakthrough in the Hidden Biology of Fusion Oncoproteins with AI

Luke Yun, AI Researcher at Harvard Medical School, shared an article by Sophia Vincoff, et al. on LinkedIn:

“Breakthrough in the Hidden Biology of Fusion Oncoproteins with AI.

Fusion oncoproteins drive many aggressive pediatric cancers, but their intrinsically disordered structures make them nearly impossible to target with traditional drug discovery methods.

A new AI model, FusOn-pLM, offers a novel approach by learning the unique properties of these elusive proteins.

Key Highlights:

  1. Fine-tuned on 44,414 fusion oncoprotein sequences – FusOn-pLM captures structural and functional features that general protein models often miss.
  2. Identifies likely resistance mutations in fusion-driven cancers, enabling novel drug resistance predictions.
  3. Outperforms leading models in predicting intrinsic disorder, puncta formation, and cellular localization, providing insights into how fusion oncoproteins drive cancer progression.
  4. Uses cosine-scheduled masked language modeling, dynamically adjusting training difficulty to improve representation quality.

Read more:

Congratulations to Sophia Vincoff, Shrey Goel, Kseniia Kholina, Rishab Pulugurta, Pranay Vure, and Pranam Chatterjee!

I share the latest developments in health AI and research insights—connect with me to stay updated! Also, check out my newsletter here.”

FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking.

Authors: Sophia Vincoff, et al.

Luke Yun: Breakthrough in the Hidden Biology of Fusion Oncoproteins with AI

 

AI biology cancer fight against cancer FusOn-pLM Global fight against cancer Harvard Medical School Kseniia Kholina Luke (Jeongwook) Yun Muhammad L. OncoDaily oncogene Oncology oncoproteins pediatric cancers Pranam Chatterjee Pranay Vure Rishab Pulugurta Shrey Goel Sophia Vincoff TranscendSci Consulting
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