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Myeloma Paper of the Day, August 3rd, Suggested by Robert Orlowski
Aug 3, 2025, 16:42

Myeloma Paper of the Day, August 3rd, Suggested by Robert Orlowski

Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:

“Myeloma Paper of the Day:

Study of BM immune ecosystem in setting of daratumumab resistance finds IFN-γ secreted by BM cells activates MYC, which correlates with resistance, as does an increase in cytotoxic CD8-positive T-cells with exhaustion phenotype.”

Title: The bone marrow immune ecosystem shapes daratumumab acquired resistance in plasma cell myeloma

Authors: Yun Wang, Shuzhao Chen, Zhijian Liang, Robert Peter Gale, Shutong Liu, Xiaoqin Chen, Peidong Chi, Yiling Song, Yingchun Zhang, Weida Wang, Juan Li, Zhongjun Xia, Yang Liang, Xiaojun Huang

You can read the Full Article on Leukemia.

Myeloma Paper of the Day, August 3rd, Suggested by Robert Orlowski

You can find more posts featuring Robert Orlowski on OncoDaily.