Michael Jain, Oncologist at Moffitt Cancer Center, shared on X:
”Great review by Saad Kenderian on the conflicting role of myeloid cells in CAR T.
IMO mice models tend to show that myeloid cells “help” and need activation while in patients it seems the myeloid cells are suppressive/inflamed and need to be reduced.”
Title: The Conflicting Role of Myeloid Cells in CAR T-Cell Therapy
Authors: Grace DeFranco, Elizabeth L Siegler, Saad S Kenderian.
You can also read ‘CAR-T Therapy: Biology, Mechanisms, Clinical Success, and Future Directions‘
