Kefah Mokbel, Chair of Breast Cancer Surgery at London Breast Institute, shared on LinkedIn:
“Omitting axillary dissection in breast cancer patients with 1 to 2 positive sentinel nodes undergoing mastectomy: a retrospective and prospective cohort study with a target trial emulation.
This is the largest observational dataset on ALND omission after mastectomy, with this framing:
In a nine-centre Chinese target trial emulation of 1090 mastectomy patients with one to two positive SLNs, SLNB alone was non-inferior to completion ALND for 5-year RFS (HR 0.83, 95% CI 0.51–1.33), though 47.7% of the SLNB-only group received three-level axillary irradiation and only 1.2% had pT3 disease.
Comment
Overall this paper has several methodological limitations and is considered hypothesis-generating at best, and it doesn’t fill the gap it claims to.”
Title: Omitting axillary dissection in breast cancer patients with one to two positive sentinel nodes undergoing mastectomy: a retrospective and prospective cohort study with a target trial emulation
Authors: Haitong Xiea, Xin Wanga, Xianlin Guc, Chihua Wue, Wanying Guof, Rui Lig, Binxu Qiua, Zhihao Zhanga, Peng Gaoa, Xiangyue Menga, Liang Duc, Shengchun Liuh, Michael Gnanti, Jie Chena.
You can also read ‘Yakup Ergün: Omitting Axillary Dissection in Breast Cancer with Sentinel-Node Metastases – SENOMAC trial‘
