Elizabeth McKenna: New Studies on KAT6/7 Histone Acetyltransferase as Therapeutic Targets in AML Published in Cancer Discovery
Elizabeth McKenna, Executive Editor of Cancer Discovery, shared a post on X:
“Now online in Cancer Discovery: back-to-back studies from the labs of Mark Dawson, Scott Armstrong, and Charles Mullighan identifying the KAT6/7 histone acetyltransferases as therapeutic targets in AML:
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia – by ShellainaGordon, Florian Perner, Scott Armstrong, Mark Dawson et al.
KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.”
Title: Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia
Authors: Shellaina J. V. Gordon, Florian Perner, Laura MacPherson, Katie A. Fennell, Daniela V. Wenge, Wallace Bourgeois, Tabea Klaus, Thomas Plenge, Anelya Murat, Jelena Petrovic, Jakub Horvath, Joan Q. Cao, John D. Lapek, Sean Uryu, Jeffrey R. White, Enid YN. Lam, Xinmeng Jasmine Mu, Yih-Chih Chan, Andrea Gillespie, Benjamin J. Blyth, Michelle A. Camerino, Ylva E. Bozikis, Henrietta Holze, Kathy Knezevic, Jesse Balic, Paul A. Stupple, Ian P. Street, Brendon J. Monahan, Shikhar Sharma, Elanor N. Wainwright, Dane Vassiliadis, Thomas A. Paul, Scott A. Armstrong, Mark A. Dawson
Title: KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
Authors: Nicole L. Michmerhuizen, Emily B. Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Vibhor Mishra, Chun Shik Park, Danika Di Giacomo, Ryan Hiltenbrand, Qingsong Gao, Sandi Radko-Juettner, Josi Lott, Cynthia Martucci, Varsha Subramanyam, Charlie Hatton, Daniela V. Wenge, Pradyuamna Baviskar, Pablo Portola, Aurelie Claquin, Bappaditya Chandra, David W. Baggett, Ali Khalighifar, Hongling Huang, Peipei Zhou, Lingyun Long, Hao Shi, Yu Sun, Evangelia K. Papachristou, Chandra Sekhar Reddy Chilamakuri, Francisca N. de Luna Vitorino, Joanna M. Gongora, Huiyun Wu, Stanley B. Pounds, Laura J. Janke, Alex Kentsis, Clive S. D’Santos, Benjamin A. Garcia, Richard W. Kriwacki, Hongbo Chi, Jeffery M. Klco, Scott A. Armstrong, Charles G. Mullighan
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