Jame Abraham, Enterprise Chairman and Professor at the Department of Hematology and Medical Oncology at Cleveland Clinic, shared on X:
“The germline EGFR T790M variant is a rare lung cancer – specific susceptibility allele that is strongly associated with lung cancer risk and enriched in individuals of Southern Appalachian ancestry through a recent founder event.
Recognition of individuals more likely to carry EGFR T790M, including those with family history of lung cancer, multifocal lung cancer, or lung nodules or Southeastern US ancestry, may help to inform future screening and prevention strategies for those at highest risk.”
Title: Germline EGFR T790M mutation and lung cancer risk
Authors: Jaclyn LoPiccolo, Steven Micheletti, Jing Shi, Wei Wang, Shubham Saini, Keng-Han Lin, Wanwan Xu, Pierre Fontanillas, Diane R. Koeller, Helen Yatzus, Victoria G. Williamson, Jose A. Avila, Raphael B. Liautaud, Noah D. Fields, Allison Harper, Virginia Kotait, Ericka Izzo, Andrew Ciupek, Courtney A. Granville, Ryan L. Collins, Judy E. Garber, David C. Christiani, Stella Aslibekyan, Julie M. Granka, Alexander Gusev, Pasi A. Jänne.
Other articles featuring Jame Abraham on OncoDaily.
