Gustavo Monnerat, Deputy Editor at The Lancet, shared on LinkedIn:
“473,000 Americans died of ischemic heart disease in 2023.
88.7% of those deaths were attributable to modifiable risk factors.
GBD 2023 in JAMA Cardiology, all 50 states, 1990 to 2023.
Top risk factors:
- High systolic blood pressure: 47.2% of IHD deaths
- Diet: 38.6%
- High LDL cholesterol: 28.5%
- High fasting plasma glucose: 18.0%
These risks overlap through shared biological pathways, so the percentages don’t sum to 100%. The age-standardized death rate is down 58.7% since 1990, but the pace has slowed.
Fasting glucose and BMI are the 2 risks still climbing. GLP-1 drugs act on both, so the next GBD cycle may read differently.
Ref: Benziger et al, . Modifiable Risk Factors and Attributable Ischemic Heart Disease Mortality in US States, 1990-2023 A Systematic Analysis for the Global Burden of Disease Study 2023. JAMA Cardiology 2026.”
Other articles about Cardio-Oncology and ischemic heart disease on OncoDaily.
