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Emmanuel S. Antonarakis: The two faces of FOXA1 mutations in prostate cancers
Jan 3, 2025, 16:58

Emmanuel S. Antonarakis: The two faces of FOXA1 mutations in prostate cancers

Emmanuel S. Antonarakis, Professor of Medicine at the University of Minnesota, shared a post on X about a recent paper by him and colleagues published in Clinical Cancer Research:

“The two faces of FOXA1 mutations in prostate cancers.

Congrats to Justin Hwang for this revised classification of FOXA1 alteration in prostate cancers.

Different FOXA1 classes have different biologic behaviors, clinical outcomes and racial clustering, especially Class 1B and 2.”

“Structurally-oriented classification of FOXA1 alterations identifies prostate cancers with opposing clinical outcomes and distinct molecular and immunologic subtypes”

Authors: Justin Hwang, Pornlada Likasitwatanakul, Sachin Kumar Deshmukh, Sharon Wu, Jason J. Kwon, Eamon Toye, David Moline, Mark G. Evans, Andrew Elliott, Rachel Passow, Christine Luo, Emily John, Nishant Gandhi, Rana R. McKay, Elisabeth I. Heath, Chadi Nabhan, Natalie Reizine, Jacob J. Orme, Josep M. Domingo Domenech, Oliver Sartor, Sylvan C. Baca, Scott M. Dehm and Emmanuel S. Antonarakis.

Emmanuel S. Antonarakis: The two faces of FOXA1 mutations in prostate cancers

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