Details on uncommon EGFR mutations in NSCLC from Dr. Alfredo Addeo
Stephen V Liu, Associate Professor of Medicine at Georgetown University, shared a post on X:
“Details on uncommon EGFR mutations in JTO & JTO CRR from Dr. Alfredo Addeo and team.
In 5212 EGFR Non-Small Cell Lung Cancer (NSCLC) dataset, 8.9% were uncommon mutations: associated with smoking history, higher rates of EGFR amp and TP53 co-mt, shorter time on TKI (4.1m) vs common (10.9m).”
Xiuning Le, Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, also shared the post on X, adding:
“In this 5,212 EGFR Non-Small Cell Lung Cancer (NSCLC) cohort, compound mutations (uncommon+ common, or uncommon+uncommon) is 12.5%, majority are EGFR PACC mutations, calling for additional clinical and research attention.”
Author: Daniele Tavernari, Maxime Borgeaud, Ximeng Liu, Parikh Kaushal, Xiuning Le, Giovanni Ciriello and Alfredo Addeo
Stephen V Liu is an Associate Professor of Medicine at Georgetown University, where he holds the positions of Director of Thoracic Oncology and Head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center. As a board-certified medical oncologist specializing in lung cancer and drug development, Dr. Liu is known for his expertise in advanced thoracic malignancies. His research focuses on novel therapeutic agents and innovative combinations to improve treatment outcomes for patients with lung cancer. Dr. Liu has received multiple teaching awards and actively engages in post-graduate education initiatives. Furthermore, he co-hosts the official podcast of the International Association for the Study of Lung Cancer (IASLC), “Lung Cancer Considered”.
Xiuning Le, MD, serves as the Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, where she oversees clinical research, including strategic planning and the operation of clinical trials within the department. She is also an Associate Professor and a leading translational researcher, specializing in resistance mechanisms, cancer genetics and genomics, biomarkers, and radiomics.
More posts featuring Stephen V Liu and Xiuning Le.
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023