Amanda Lund, Associate Professor at NYU Langone Health, shared on LinkedIn:
“Preclinical studies suggest that tumor cells undergo phenotypic adaptations to seed and grow within regional lymph nodes. Yet lymph node metastasis is still often treated as a passive waypoint in systemic progression …a binary indicator of aggressive disease.
In our new bioRxiv preprint, we asked whether human melanomas show evidence of active adaptation and evolution during lymph node colonization.
Using spatial transcriptomics and highly multiplexed imaging of paired primary tumors and sentinel lymph node metastases, we reconstructed trajectories of melanoma evolution across these sites. We find that lymph node colonization is associated with continued tumor evolution, phenotypic adaptation, and immune escape. This regional biology is associated with systemic outcomes, suggesting that biological heterogeneity within lymph node metastases may be a rich, and largely untapped, resource for patient stratification.”
Title: Melanoma evolution in the lymph node shapes systemic outcomes
Authors: Katherine S. Ventre, Tara Muijlwijk, Robert Stagnitta, Shi Qiu, Ze Chen, Irineu Illa Bochaca, Ata S. Moshiri, Teresa Davoli, Iman Osman, Itai Yanai, Markus Schober, Amanda W. Lun
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