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Oliver Maracic: N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10
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Mar 25, 2025, 10:28

Oliver Maracic: N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10

Oliver Maracic, Investor, shared an article by Leyi Huang, et al. on LinkedIn:

“Tumor-induced PNI can be observed in over 80% of patients with PDAC, significantly impacting their prognosis.

  • Perineural invasion (PNI) is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC), which occurs at a high incidence and significantly contributes to PDAC lethality and poor survival.
  • Combining small-molecule inhibitors targeting NAT10 and focal adhesion kinase (FAK) significantly attenuated PNI in vivo.
  • N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma.”

Oliver Maracic: N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10

N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10 promotes perineural invasion in pancreatic ductal adenocarcinoma.

Authors: Leyi Huang, et al.

Oliver Maracic: N4-acetylcytidine modification of ITGB5 mRNA mediated by NAT10

acetylcytidine cancer fight against cancer Global fight against cancer ITGB5 Leyi Huang mRNA NAT10 Oliver Maracic OncoDaily Oncology pancreatic ductal adenocarcinoma PDAC Perineural invasion
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