Patrick Hwu: How can we make cancer vaccines more effective?
Patrick Hwu, President and CEO of Moffitt Cancer Center, shared a post on X about a recent paper by Dmitrij Ostroumov et al. published in Nature:
“Cancer Vaccines are being intensively studied and may one day become an important modality to treat cancer and prevent recurrence.
But how can we make them more effective?
In this study, investigators combined a liposomal formulation of tumor antigens and STING agonists for the initial vaccination in order to load and activate dendritic cells.
They then boosted the vaccine one week later with an agonistic CD40 antibody resulting in explosive proliferation of antigen-specific T cells and regressions of large tumors in murine models.
This prime-boost approach holds promise for future clinical trials of cancer vaccines.”
Authors: Dmitrij Ostroumov, Naomi Benne, Fernando Lozano Vigario, Oscar Escalona-Rayo, Ksenia Dodz, Sarah Sauer, Lena Luisa Suhl, Hans Heiner Wedemeyer, Florian Kühnel, Bram Slütter and Thomas Christian Wirth
Dr. Patrick Hwu, MD, currently serves as the President and CEO of Moffitt Cancer Center. With a focus on understanding the dynamics between tumors and the immune system, Dr. Hwu’s research has been pivotal in advancing gene-modified T-cell therapy.
He notably contributed seminal work on the development of the first chimeric antigen receptor aimed at combating cancer. His research portfolio extends to vaccines, adoptive T-cell therapies, and mechanisms of immune resistance.
Before joining, Dr. Hwu held numerous leadership roles at The University of Texas MD Anderson Cancer Center for over 17 years.
Notably, he served as the inaugural Chairman of the Department of Melanoma Medical Oncology in 2003, as well as the Associate Director of the Center for Cancer Immunology Research. Additionally, he chaired the Department of Sarcoma Medical Oncology, demonstrating his commitment to advancing cancer treatment and research.
More posts featuring Patrick Hwu.
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023