Manni Mohyuddin: If a randomized trial fails

Manni Mohyuddin, Assistant Professor at the Huntsman Cancer Institute at the University of Utah, shared on X/Twitter:

“If a randomized trial fails-

But you do a per-protocol (not ITT) analysis of a subset of patients and show that it works for them

You’ve essentially removed a huge benefit of randomization (adjusting for all confounders).

May as well call this an observational study then.”

Source: Manni Mohyuddin/X