Shui Yen Soh

Dr. Shui Yen Soh is a pediatric hematologist/oncologist specializing in pediatric hematology and oncology. She currently serves as Head and Senior Consultant of the Pediatric Hematology/Oncology Service at KK Women’s and Children’s Hospital (KKH), Singapore, while holding academic appointments as Clinical Assistant Professor at Duke-NUS Medical School and Adjunct Assistant Professor at the NUS Yong Loo Lin School of Medicine. Her work spans a broad range of pediatric oncology and hematology research, including neuroblastoma, Wilms tumor, leukemia, CAR T-cell therapy, hemophagocytic lymphohistiocytosis, and rare pediatric tumors.

Current Position

• Head and Senior Consultant, Pediatric Hematology/Oncology Service — KK Women’s and Children’s Hospital (KKH), Singapore (May 2001 – Present)
• Clinical Assistant Professor — Duke-NUS Medical School (July 2013 – Present)
• Adjunct Assistant Professor — NUS Yong Loo Lin School of Medicine

Education

• Raffles Junior College
• National University of Singapore

Professional Experience

• Senior Consultant Pediatrician, Hematology/Oncology Service — KK Women’s & Children’s Hospital, Singapore (May 2001 – Present)
• Clinical Assistant Professor — Duke-NUS Medical School (July 2013 – Present)
• Oncology Fellow — The Hospital for Sick Children, Toronto, Canada (February 2009 – January 2010)

Research Activity

• Neuroblastoma biology, genomics, and patient-derived models
• Wilms tumor clinicopathological and genomic characteristics in Asian populations
• Pediatric leukemia, including CAR T-cell therapy for B-lineage acute lymphoblastic leukemia
• Pediatric solid tumors and multidisciplinary tumor board practices in low- and middle-income countries
• Hemophagocytic lymphohistiocytosis (HLH) in children
• Pediatric brain tumors, including glioblastoma, medulloblastoma, and epidural sarcomas
• Retinoblastoma clinical profile and outcomes
• Pediatric hepatocellular carcinoma and hepatitis B virus seropositivity
• Rhabdomyosarcoma histomolecular subtypes in Asian populations
• Cancer predisposition syndromes in childhood tumors
• Late effects in childhood cancer survivors
• Thalassemia and hematological disorders in children
• Central line-associated bloodstream infection prevention in pediatric oncology patients

Areas of Specialization

• Pediatric hematology
• Pediatric oncology
• Neuroblastoma
• Wilms tumor
• Pediatric leukemia and CAR T-cell therapy
• Pediatric brain and solid tumors
• Hemophagocytic lymphohistiocytosis
• Retinoblastoma
• Cancer predisposition syndromes in children

Publications

Dr. Shui Yen Soh has an extensive publication record spanning over two decades, with contributions to leading journals in pediatric oncology, hematology, and genomics, including Nature Biomedical Engineering, Nature Communications, Blood, International Journal of Cancer, Frontiers in Oncology, and Pediatric Blood & Cancer. Selected publications are listed below.

Selected Publications

Mok Y, Goh JY, Kuick CH, et al. Chang KTE. Clinical implementation of targeted panel sequencing for paediatric tumours: findings and outcomes in a Southeast Asian cohort. Pathology. May 2026.
Wong MK, Lim KT, Thùy ĐTN, et al. Loh A. Gain of Chromosome 1q and MYCN Characterize Unique Subgroups of Asian Wilms Tumor Patients. Cancer Treatment and Research Communications. March 2026.
Jagannathan NS, Sin WX, Teo DBL, et al. Ram RJ. Dynamic estimation of metabolic state during CAR T cell production. Cell Reports Methods. February 2026.
Lee MW, Barton R, Tan E, et al. Moshi G. Trisomy 21 and GATA1 mutation in clonal proliferation: case series of non-classical presentations in individuals with and without Down syndrome. Pathology. February 2026.
Leen JLS, Leong K, Tan DJL, et al. Seng MSF. The reported late effects experienced by childhood cancer survivors treated in Singapore: A clinical audit. Annals of the Academy of Medicine Singapore. November 2025.
Ong R, Loe MWC, Chan B, et al. Tan NW. Evaluation of an Accelerated Hepatitis B Vaccination Schedule in Post-Hematopoietic Stem Cell Transplant Pediatric Patients. Pediatric Blood & Cancer. November 2025.
Seng M, Soh SY, Hwang W, et al. Leung W. Multiomic signatures of durable response in a Phase I/II trial of tandem aCD22-aCD19 CAR-T therapy for relapsed B-lineage acute lymphoblastic leukaemia. Blood. November 2025.
Kwek K, Quek KY, Sin WX, et al. Han J. Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes. Nature Communications. May 2025.
Jagannathan NS, Sin WX, Teo DBL, et al. Ram RJ. Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product. Preprint. May 2025.
Lim HY, Viegelmann G, Lee EY, et al. Tan NW. Fever of Unknown Origin in Children: A 14-Year, Single Institution Retrospective Review. Sage Open Pediatrics. April 2025.
Seng M, Soh SY, Lim FWi, et al. Leung WH. Manufacturing Characteristics and Early Outcomes of a Tandem aCD22-aCD19 CAR-T Therapy for Childhood and Adult Relapsed/Refractory Acute Precursor B Lymphoblastic Leukemia. Transplantation and Cellular Therapy. February 2025.
Chong H, Liew GSM, et al. Iyer P. Bridging the gap: Integrating RNA-sequencing with conventional markers for high-resolution risk-assessment in B-ALL. Pediatric Hematology Oncology Journal. January 2025.
Ong JLK, Jalaludin NFF, Wong MK, et al. Loh A. Exosomal mRNA Cargo are biomarkers of tumor and immune cell populations in pediatric osteosarcoma. Translational Oncology. June 2024.
Sin WX, Jagannathan NS, Teo DBL, et al. Birnbaum ME. A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells. Nature Biomedical Engineering. June 2024.
Meng J, Ng KS, Ye JF, et al. Lim FWi. 431 LongiBloodImmunoM: longitudinal blood-based immunomonitoring of CAR-T cell therapy patients for predictive biomarkers. Journal for ImmunoTherapy of Cancer. October 2023.
Looi WS, Tan AM, Soh SY, et al. Wong RX. Long-term survival after reduced-dose radiotherapy in pediatric nasopharyngeal carcinoma. Preprint. September 2023.
Loh A, Thura M, Gupta A, et al. Zeng Q. Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody. Molecular Therapy — Oncolytics. August 2023.
How GY, Kuick CH, Yong MH, et al. Loh A. Clinicopathological and treatment response characteristics of updated rhabdomyosarcoma histomolecular subtypes: An Asian population-based study. Asia-Pacific Journal of Clinical Oncology. July 2023.
Seng M, Meierhofer AC, Lim FL, et al. Hwang WYK. A Review of CAR-T Therapy in Pediatric and Young Adult B-Lineage Acute Leukemia: Clinical Perspectives in Singapore. OncoTargets and Therapy. March 2023.
Wong MRE, Lim KH, Hee E, et al. Loh A. Targeting Mutant Dicer Tumorigenesis in Pleuropulmonary Blastoma via Inhibition of RNA Polymerase I. Translational Research. March 2023.
Ong R, Seah XFV, Chong CY, et al. Kam KQ. A cohort study of COVID-19 infection in pediatric oncology patients and the utility of remdesivir treatment. Preprint. October 2022.
Loh A, Angelina C, Wong MK, et al. Chen ZX. Pro-metastatic and mesenchymal gene expression signatures characterize circulating tumor cells of neuroblastoma patients with bone marrow metastases and relapse. Frontiers in Oncology. September 2022.
Kuick CH, Tan JY, Jasmine D, et al. Loh A. Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma. BMC Cancer. June 2022.
Matthay KK, Hylton J, Penumarthy N, et al. Howard SC. Global Neuroblastoma Network: An international multidisciplinary neuroblastoma tumor board for resource-limited countries. Pediatric Blood & Cancer. January 2022.
Monsereenusorn C, Alcasabas AP, Loh A, et al. Rodriguez-Galindo C. Impact of treatment refusal and abandonment on survival outcomes in pediatric osteosarcoma in Southeast Asia: A multicenter study. Pediatric Blood & Cancer. January 2022.
Lim KHT, Kong HL, Chang KTE, et al. Aung L. Recommended testing algorithms for NTRK gene fusions in pediatric and selected adult cancers: Consensus of a Singapore Task Force. Asia-Pacific Journal of Clinical Oncology. November 2021.
Wong RLY, Wong MRE, Kuick CH, et al. Loh A. Integrated Genomic Profiling and Drug Screening of Patient-Derived Cultures Identifies Individualized Copy Number-Dependent Susceptibilities Involving PI3K Pathway and 17q Genes in Neuroblastoma. Frontiers in Oncology. October 2021.
Halepota HF, Tan JSK, Reddy S, et al. Loh A. Association of anesthetic and surgical risk factors with outcomes of initial diagnostic biopsies in a current cohort of children with anterior mediastinal masses. World Journal of Pediatric Surgery. October 2021.
Lam JCM, Lee SY, Koh PL, et al. Ang AL. Clinical and health-related quality of life outcomes of transfusion-dependent thalassaemia patients in Singapore. Blood Cells, Molecules, and Diseases. February 2021.
Sutiman N, Nwe MS, Lai EEN, et al. Tan AM. Excellent Survival Outcome of Pediatric Patients with Acute Myeloid Leukemia Treated on MASPORE 2006 Protocol. Clinical Lymphoma, Myeloma and Leukemia. December 2020.
Liu AP, Soh SY, Cheng FWC, et al. Chiang AKS. Hepatitis B Virus Seropositivity Is a Poor Prognostic Factor of Pediatric Hepatocellular Carcinoma: a Population-Based Study in Hong Kong and Singapore. Frontiers in Oncology. November 2020.
Othman MY, Blair S, Nah SA, et al. Loh A. Pediatric Solid Tumor Care and Multidisciplinary Tumor Boards in Low- and Middle-Income Countries in Southeast Asia. JCO Global Oncology. November 2020.
Hee E, Wong MK, Tan SH, et al. Loh A. Neuroblastoma patient-derived cultures are enriched for mesenchymal gene signature and reflect individual drug response. Cancer Science. August 2020.
Quek CWN, Foong YW, Tan SK, et al. Koh MJA. Leukemia cutis in a child with juvenile myelomonocytic leukemia presenting with Sweet’s syndrome-like lesions and secondary to juvenile myelomonocytic leukemia in a child with a history of multiple juvenile xanthogranulomas. JAAD Case Reports. August 2020.
Tan LQ, Nagaputra JC, Soh SY, et al. Low SYY. Extraneural metastatic paediatric glioblastoma: Case report and literature review. Journal of Clinical Neuroscience. April 2020.
Tip SWM, Lee YT, Tang PH, et al. Loh A. Retroperitoneal Tumors and Congenital Vascular Anomalies of Retroperitoneal Great Vessels. Journal of Pediatric Surgery. October 2019.
Chong CY, Ong R, Seah XFV, et al. Thoon KC. Taurolidine–citrate lock solution for the prevention of central line-associated bloodstream infection in paediatric haematology–oncology and gastrointestinal failure patients with high baseline central-line associated bloodstream infection rates. Journal of Paediatrics and Child Health. May 2019.
Low SYY, Kuick CH, Seow WY, et al. Low CY. Primary paediatric epidural sarcomas: Molecular exploration of three cases. BMC Cancer. February 2019.
Loke BN, Wong MK, Tawng KD, et al. Loh A. Clinical, pathological and loss of heterozygosity differences in Wilms tumors between Asian and non-Asian children. International Journal of Cancer. December 2018.
Chan SH, Chew W, Ishak D, et al. Ngeow J. Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours. npj Genomic Medicine. December 2018.
Kam KQ, Soh SY, Bhattacharyya R. Dengue-associated Hemophagocytic Lymphohistiocytosis: A Rare Complication of a Common Infection in Singapore. Journal of Pediatric Hematology/Oncology. December 2017.
Hong W, Chew W, Courtney EK, et al. Ngeow J. Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing. Molecular Genetics & Genomic Medicine. July 2017.
Leow E, Soh SY, Tan AM, et al. Lee JH. Critically Ill Children With Hemophagocytic Lymphohistiocytosis: A Case Series of 14 Patients. Journal of Pediatric Hematology/Oncology. July 2017.
Low SYY, Soh SY, Chen MW, et al. Seow WT. DTI fusion with conventional MR imaging in intra-operative MRI suite for paediatric brainstem glioma biopsy. Child’s Nervous System. October 2017.
Choo Z, Koh RYL, Wallis K, et al. Chen ZX. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget. April 2016.
Yan B, Kuick CH, Lim M, et al. Chang KTE. Characterization of anaplastic lymphoma kinase-positive medulloblastomas. Journal of Clinical Neuroscience. October 2015.
Lee RQK, Farid M, et al. Dandawala ALS. Singapore Cancer Network (SCAN) Guidelines for the Initial Evaluation, Diagnosis, and Management of Extremity Soft Tissue Sarcoma and Osteosarcoma. Annals of the Academy of Medicine Singapore. October 2015.
Quek R, Farid M, et al. Ong SAK. Singapore Cancer Network (SCAN) Guidelines for the Initial Evaluation, Diagnosis and Management of Retroperitoneal Soft Tissue Sarcoma. Annals of the Academy of Medicine Singapore. October 2015.
Koh V, Soh SY, Chan MY, Tan AM. Neuroblastoma in Children Under 12 Months in Singapore—15-Year Experience and Outcomes From KKH. Fetal and Pediatric Pathology. January 2015.
Yan B, Kuick CH, Lim M, et al. Chang KTE. Platform Comparison for Evaluation of ALK Protein Immunohistochemical Expression, Genomic Copy Number and Hotspot Mutation Status in Neuroblastomas. PLOS One. September 2014.
Liu AP, Shing MK, Yuen H-L, et al. Ribeiro KB. Epidemiology of CNS tumors in children below age three. Neuro-Oncology. June 2014.
Littooij AS, Kwee TC, Barber I, et al. Nievelstein RAJ. Whole-body MRI for initial staging of paediatric lymphoma: Prospective comparison to an FDG-PET/CT-based reference standard. European Radiology. February 2014.
Lam JCM, Soh SY, Law HY. Clinical and haematological features of Non-Deletional alpha thalassaemia mutations in Singapore. Pathology. February 2014.
Morgenstern D, Soh SY, Stavropoulos DJ, et al. Irwin MS. Metachronous Neuroblastoma in an Infant With Germline Translocation Resulting in Partial Trisomy 2p: A Role for ALK? Journal of Pediatric Hematology/Oncology. October 2013.
Foo A, Dawn CQQ, Kenneth CTE, Kian TC. Primary human chorionic gonadotropin secreting germinoma of the corpus callosum. Surgical Neurology International. October 2013.
Entesarian M, Chiang SCC, Schlums H, et al. Bryceson Y. Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3. British Journal of Haematology. May 2013.
Lim FPM, Soh SY, Iyer JV, et al. Quah BL. Clinical Profile, Management, and Outcome of Retinoblastoma in Singapore. Journal of Pediatric Ophthalmology and Strabismus. March 2013.
Hasselblatt M, Kordes U, Wolff JE, et al. Narendran A. Atypical Teratoid Rhabdoid Tumor (ATRT). Neuro-Oncology. June 2012.
Soh SY, Dimaras H, Gupta AA, Chan HSL. Adult Ovarian Retinoblastoma Genomic Profile Distinct From Prior Childhood Eye Tumor. JAMA Ophthalmology. August 2011.
Soh SY, Chan MY, Tan AM. O04 Our experience with the Hong Kong-Singapore Acute Lymphoblastic Leukaemia 97 protocol. Blood Reviews. August 2007.
Soh SY, Yeo GSH, Tan AM. P092 Severe foetal and neonatal anaemia due to Kell alloimmunization. Blood Reviews. August 2007.
Tee NWS, Soh SY, Lin R, Loo LH. Staphylococcus lugdunensis Carrying the mecA Gene Causes Catheter-Associated Bloodstream Infection in Premature Neonate. Journal of Clinical Microbiology. January 2003.