Dana-Farber News shared on X:
“Researchers co-led by Kimmie Ng of Dana-Farber and Dana-Farber’s Young-Onset Colorectal Cancer Center created the largest single-cell atlas of colorectal cancer ever, identifying age-associated differences that may help research into why colorectal cancer can be more aggressive in younger adults.”
Kimmie Ng, Director of Dana-Farber’s Young-Onset Colorectal Cancer Center, added:
“Our atlas of young-onset CRC is finally out in Nature Medicine! We found a unique biology in younger patients that may explain the aggressive nature of this disease. This was a monumental effort with colleagues at Mass General Brigham and Broad Institute.”
Title: Insights into early-onset colorectal cancer from a single-nucleus RNA-seq atlas of colorectal cancer across the age continuum
Authors: Caroline B. M. Porter, Shane P. Murphy, Jules Cazaubiel, Toni M. Delorey, Liat Amir-Zilberstein, Orr Ashenberg, Liubou Klindziuk, Elizabeth Andrews, William Tan, Kosuke Matsuda, Atsushi Kondo, Satoko Ugai, Tomotaka Ugai, Shuji Ogino, Emily Finan, Jacques Deguine, Ewa Sicinska, Lauren K. Brais, Jennifer S. Thalappillil, Marios Giannakis, Ramnik J. Xavier, Ana C. Anderson, Kimmie Ng.
Read the full article.
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