Stephen Liu: What is the best way to assess response of brain metastases to systemic treatment?
Stephen Liu, Associate Professor at Georgetown Lombardi Comprehensive Cancer Center, shared a post on X:
“What is the best way to assess response of brain metastases to systemic treatment?
This report, Journal of Clinical Oncology from patients with melanoma treated with nivolumab and ipilimumab in CheckMate 204 compared modified RECIST vs RANO-BM vs volumetric analyses.
If you do not factor in the clinical deterioration assessment of RANO-BM, it performs as well as mRECIST. Suggestion that 5mm could be used as a size cutoff rather than 10mm.
Volumetric analysis correlated with survival. Is it time to explore more use of volumetric analyses?”
Authors: Raymond Y. Huang, Gilbert Youssef, Thomas Nelson, Patrick Y. Wen, Peter Forsyth, F. Stephen Hodi, Kim Margolin, Alain P. Algazi, Omid Hamid, Christopher D. Lao, Marc S. Ernstoff, Stergios J. Moschos, Michael B. Atkins, Michael A. Postow, David A. Reardon, Diederik J. Grootendorst, David Leung, Margarita Askelson, Corey Ritchings, Hussein A. Tawbi.
Stephen V Liu is an Associate Professor of Medicine at Georgetown University, where he holds the positions of Director of Thoracic Oncology and Head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center. As a board-certified medical oncologist specializing in lung cancer and drug development, Dr. Liu is known for his expertise in advanced thoracic malignancies.
His research focuses on novel therapeutic agents and innovative combinations to improve treatment outcomes for patients with lung cancer. Dr. Liu has received multiple teaching awards and actively engages in post-graduate education initiatives. Furthermore, he co-hosts the official podcast of the International Association for the Study of Lung Cancer (IASLC), “Lung Cancer Considered”.
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