Paolo Tarantino: Thanks to NSABP-B51, Countless Patients Will Be Spared the Toxicity of Nodal Irradiation
Paolo Tarantino, 2025 Yvonne ‘Top Voice’ Award Winner, Research Fellow at Dana-Farber Cancer Institute, shared a post on X by NEJM, about a paper by Eleftherios P. Mamounas et al. published in NEJM:
“In oncology, we don’t usually love overlapping Kaplan-Meier curves. Except that sometimes we really do. Thanks to NSABP-B51, countless patients will be spared the toxicity of nodal irradiation, and many will live free from a permanent lymph edema that would have impacted their lives.”
Quoting NEJM’s post:
“In women with node-positive breast cancer whose nodes became free of disease after neoadjuvant therapy, regional nodal irradiation did not reduce breast cancer recurrence or improve survival. Full results from a phase 3 trial.”
Title: Omitting Regional Nodal Irradiation after Response to Neoadjuvant Chemotherapy
Authors: Eleftherios P. Mamounas, Hanna Bandos, Julia R. White, Thomas B. Julian, Atif J. Khan, Simona F. Shaitelman, Mylin A. Torres, Frank A. Vicini, Patricia A. Ganz, Susan A. McCloskey, Peter C. Lucas, Nilendu Gupta, X. Allen Li, Beryl McCormick, Benjamin Smith, Rahul D. Tendulkar, Vivek S. Kavadi, Koji Matsumoto, Samantha Andrews Seaward, William J. Irvin Jr., Jolinta Y. Lin, Robert W. Mutter, Thierry M. Muanza, Jannifer Stromberg, Reshma Jagsi, Anna C. Weiss, Walter J. Curran Jr., Norman Wolmark
You can read the Full Article in NEJM.
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