Maria Babak: The potential of transition metal complexes in combating emerging cancer hallmarks
Maria Babak, Haed of The Babak Lab, shared a post on LinkedIn by The Babak Lab, about an article she co-authored with colleagues, published in Coordination Chemistry Reviews:
“Our lab’s research highlights the potential of transition metal complexes in combating emerging cancer hallmarks, an important challenge in cancer treatment.
Targeting cancer stem cells (CSCs) is crucial for preventing metastasis and recurrence, and transition metal complexes offer a promising avenue for developing more effective therapies.”
Quoting The Babak Lab’s post:
“Scientific Wednesday։ Transition metal complexes as an approach for targeting emerging cancer hallmarks
Over the past decade, our understanding of cancer’s complexity has deepened significantly. Research has unveiled how cancer cells acquire specific hallmarks to transform into malignant cells.
For today’s Scientific Wednesday post, we would like to invite our readers to have a read of our review, published in 2022. This article sheds light on innovative strategies for targeting cancer stem cells (CSCs) and the tumor microbiome using transition metal complexes.
Key takeaways:
- Phenotypic plasticity drives cancer cell invasion and metastasis.
- Epigenetic reprogramming regulates nonmutational changes influencing cell states.
- Transition metals are pivotal in the tumor microenvironment (TME), impacting cancer progression and treatment response.
- Microbiome interactions with transition metals unveil potential for innovative therapies.
To find out more about which transition metal complexes were found to deplete cancer stem cells (CSCs), access the article using the following link.”
Authors: Meng Chang, Daniil Rusanov, Jemma Arakelyan, Mana Alshehri, Aleksandra Asaturova, Galina Kireeva, Maria Babak, Wee Ang.
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