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Hassan R. Hashmi: Are We Entering a New Era Where Physical Activity Becomes an Adjuvant Modality in Immuno-Oncology?

Hassan R. Hashmia/LinkedIn

Jul 13, 2025, 12:29

Hassan R. Hashmi: Are We Entering a New Era Where Physical Activity Becomes an Adjuvant Modality in Immuno-Oncology?

Hassan R. Hashmi, General and Colorectal Surgeon at Las Vegas Surgical Associates, shared Syed A. Ahmad’s post on X:

“Fascinating how physical activity can shape the microbiome to enhance CD8 T cell-driven antitumor immunity.

Could this help explain the improved outcomes seen in CRC patients with greater physical activity?

Compelling synergy between this Cell study and the CHALLENGE trial (NEJM):

Exercise -> Microbiota metabolites -> Enhanced CD8 T cell-mediated tumor immunity.

CHALLENGE trial: Structured exercise improved disease-free survival in colon cancer survivors.

Are we entering a new era where physical activity becomes an adjuvant modality in immuno-oncology?”

Syed A. Ahmad, Director at University of Cincinnati Cancer Center, shared on X about a recent paper by Catherine M. Phelps et al. published in Cell:

“Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy.”

Title: Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Authors: Catherine M. Phelps, Nathaniel B. Willis, Tingting Duan, Amanda H. Lee, Yue Zhang, Daphne M. Rodriguez J, Surya P. Pandey, Colin R. Laughlin, Aaron B.I. Rosen, Alex C. McPherson, Jake H. Shapira, Simran K. Randhawa, Lee Hedden, Tanner G. Richie, Hallie M. Wiechman, Mackenzie J. Bender, Ina Nemet, Patrick A. Zöhrer, Rachel A. Gottschalk, Kathryn H. Schmitz, Steven J. Mullett, Stacy L. Gelhaus, Diwakar Davar, Hassane M. Zarour, Reinhard Hinterleitner, Thomas Mossington, Jonathan H. Badger, Richard R. Rodrigues, John A. McCulloch, Sonny T.M. Lee, Karl-Heinz Wagner, Maria G. Winter, Sebastian E. Winter, Jishnu Das, Joseph F. Pierre, Giorgio Trinchieri, Marlies Meisel.

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More posts featuring Hassan R. Hashmi.

Aaron B.I. Rosen Alex C. McPherson Amanda H. Lee cancer Catherine M. Phelps CHALLENGE trial Colin R. Laughlin colorectal cancer CRC patients Daphne M. Rodriguez J Diwakar Davar Giorgio Trinchieri Hallie M. Wiechman Hassan R. Hashmi Hassane M. Zarour immunotherapy Ina Nemet Jake H. Shapira Jishnu Das John A. McCulloch Jonathan H. Badger Joseph F. Pierre Karl-Heinz Wagner Kathryn H Schmitz Lee Hedden Mackenzie J. Bender Maria G. Winter Marlies Meisel Nathaniel B. Willis OncoDaily Oncology Patrick A. Zöhrer Rachel A. Gottschalk Reinhard Hinterleitner Richard R. Rodrigues Sebastian E. Winter Simran K. Randhawa Sonny T.M. Lee Stacy L. Gelhaus Steven J. Mullett Surya P. Pandey Syed A. Ahmad Tanner G. Richie Thomas Mossington Tingting Duan Yue Zhang

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