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Arndt Vogel: Shallow WGS of Circulating Tumour DNA Predicts Clinical Outcomes to Systemic Therapy in HCC
Arndt Vogel/aasld.org
Aug 2, 2025, 13:16

Arndt Vogel: Shallow WGS of Circulating Tumour DNA Predicts Clinical Outcomes to Systemic Therapy in HCC

Arndt Vogel, Head of the Center for Personalized Medicine, MHH at Hannover Medical School, shared a post on X about a recent article by Venkata Ramana Mallela et al. published in European Journal of Cancer:

“Shallow whole-genome sequencing of circulating tumour DNA predicts clinical outcomes to systemic therapy in HCC

  • sWGS enables evaluation of ctDNA
  • High TF and fragmentation associated with poor prognosis
  • TF predicts progression-free survival independently
  • promising prognostic biomarker”

Title: Shallow whole-genome sequencing of circulating tumour DNA predicts clinical outcomes to systemic therapy in advanced hepatocellular carcinoma

Authors: Venkata Ramana Mallela, Sultan N. Alharbi, Mathew Vithayathil, Caroline Ward, Rishi Patel, Rohini Sharma

Read the Full Article on European Journal of Cancer

Arndt Vogel: Shallow WGS of Circulating Tumour DNA Predicts Clinical Outcomes to Systemic Therapy in HCC

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