Challenges in delivering radiotherapy to lymph nodes in rectal cancer

Nina Niu Sanford shared a post by Ane Appelt, Associate Professor at the University of Leeds, on X, adding:           .

“Nice paper. I find the treatment of lymph nodes challenging in rectal cancer.

In OCUM study, MRI accuracy for predicting LN (lymph nodes) involvement at diagnosis only 56% (basically a coin flip).

And then post neoadjuvant treatment even trickier (and some completely disappear).”

Quoting Ane Appelt’s post:

“How much margin do we need on individual lymph nodes when delivering rectal cancer radiotherapy?

Dennis Tideman Arp ran a prospective MRI study (physicist as PI (Principal Investigator)!) and estimated node position variation over the course of RT (Radiation therapy).”

Proceed to the article.
Source: Nina Niu Sanford/X and Ane Appelt/X

Dr. Nina Niu Sanford is an Assistant Professor and Chief of Gastrointestinal Radiation Oncology at Harvard/Brigham and Women’s Hospital/Massachusetts General Hospital. She specializes in treating gastrointestinal cancers and actively participates in clinical trials combining high-dose radiation therapy with immunotherapy. Additionally, she researches healthcare access disparities and conducts pan-cancer outcomes research using large databases.