Patrick Hwu: What is pyroptosis and how can it activate an antitumor immune response?

Patrick Hwu, President and CEO at Moffit Cancer Center, shared on X/Twitter:

“What is pyroptosis and how can it activate an antitumor immune response?
Pyroptosis is a kind of cell death distinct from apoptosis that is characterized by cell swelling and release of inflammatory mediators. In this study, investigators found that tumor death by pyroptosis as opposed to apoptosis led to activation of dendritic cells and induction of long-lived functional antitumor CD8+ T-cells. This guides future research to test agents which cause cancer cell pyroptosis in combination with immunotherapy.

Here’s a link to the full study.”

Source: Patrick Hwu/X

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