Yu-Hung Wang: Loss of Dnmt3a increases self-renewal of JAK2V617F HSCs

Yu-Hung Wang, PhD student at The University of Manchester, shared on X/Twitter:

“Loss of Dnmt3a increases self-renewal of JAK2V617F HSCs and mitigates their attrition upon chronic pegIFNα Rx -A combination of pegIFNα and AZA can strongly decrease the JAK2-mut allele burden in MPN driven by JAK2V617F alone.”

Additional information.
Source: Yu-Hung Wang/X