Anirban Maitra: The importance of the gut microbiome homeostasis on distant tumor growth

Anirban Maitra, Scientific Director of the Pancreatic Cancer Research Center at MD Anderson Cancer Center, shared the following insight on X/Twitter:

“HUGE congratulations to Florencia McAllister, Vidhi Chandra and colleagues from MD Anderson Cancer Center for their Cancer Cell paper (cameo by Pylayeva-Gupta).

Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation.
This paper establishes the complex and compartment-specific roles (gut versus tumor microenvironment) of the IL17-IL17RA axis. IL17RA is required for maintaining gut microbiome homeostasis. Deletion of IL17RA in the gut leads to microbial dysbiosis and enhances homing of tumor-promoting Th17 cells and B cells to the tumor milieu, where IL-17 secretion promotes DUOX2-mediated tumor growth. This effect is seen in both Pancreatic Cancer and Brain Cancers, underscoring the importance of the gut microbiome homeostasis on distant tumor growth.”

Source: Anirban Maitra/X