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Raghav Sundar: Understanding Resistance Mechanisms in HER2+ Gastric Cancer
Raghav Sundar/X
Nov 11, 2024, 03:14

Raghav Sundar: Understanding Resistance Mechanisms in HER2+ Gastric Cancer

Raghav Sundar, Leader Gastroesophageal Cancer Program, Associate Professor of Medicine (Oncology), Yale University School of Medicine and Yale Cancer Center, posted the following on X:

“Cancers develop resistance to targeted therapies. Most studies on acquired resistance have focused on tumor cells and not the microenvironment. We outline spatial mechanisms of resistance to trastuzumab and T-DXd in HER2+ Gastric Cancer.”

Spatial Profiling of Patient-Matched HER2 Positive Gastric Cancer Reveals Resistance Mechanisms to Trastuzumab and Trastuzumab Deruxtecan

Authors: Taotao Sheng, Raghav Sundar, Supriya Srivastava, Xuewen Ong, Su Ting Tay, Haoran Ma, Tomoyuki Uchihara, Benedict Shi Xiang Lian, Takeshi Hagihara, Chang Xu, Shamaine Wei Ting Ho, Kie Kyon Huang, Angie Lay Keng Tan, Michelle Shu Wen NG, Ng Shi Ya Clara, Vincenzo Nasca, Chiara Carlotta Pircher, Giovanni Randon, Silvia Giordano, Simona Corso, Jeffrey Huey Yew Lum, Ming Teh, Jimmy Bok Yan So, Jessica Gasparello, Matteo Fassan, Filippo Pietrantonio, Patrick Tan

Raghav Sundar: Understanding Resistance Mechanisms in HER2+ Gastric Cancer

 

Angie Lay Keng Tan Benedict Shi Xiang Lian cancer cancer microenvironment Cancer research cancer resistance cancer treatment Chang Xu Chiara Carlotta Pircher clinical oncology Filippo Pietrantonio gastric cancer Giovanni Randon Haoran Ma HER2+ gastric cancer Jeffrey Huey Yew Lum Jessica Gasparello Jimmy Bok Yan So Kie Kyon Huang Matteo Fassan Medical Research Michelle Shu Wen NG Ming Teh Molecular Mechanisms Ng Shi Ya Clara OncoDaily Oncology Patrick Tan Raghav Sundar Shamaine Wei Ting Ho Silvia Giordano Simona Corso Su Ting Tay Supriya Srivastava T-Dxd Takeshi Hagihara Taotao Sheng targeted therapies therapeutic resistance Tomoyuki Uchihara trastuzumab Vincenzo Nasca Xuewen Ong Yale Cancer Center Yale University School of Medicine
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