Diego Adrianzen-Herrera: Our study on MDS and autoimmune disease in Blood Advances

Diego Adrianzen-Herrera, Assistant Professor of Medicine UVM Larner Med, shared a post on Twitter, saying:

“Our study on MDS and autoimmune disease (AD) in Blood Advances.

A population analysis in NCI Healthcare Delivery Research (HDRP)‘s SEER-Medicare database: 15,227 MDS patients, 16% with AD.

Preexisting AD associated with 11% decreased risk of mortality (any cause). Systemic immunosuppression preceding MDS in ~7% patients and associated with 10% increased mortality. Preexisting AD associated with higher transfusion dependence but no difference in HMA/HSCT use.

Effect of preexisting AD on the risk of AML differed depending on histology.
Preexisting AD linked to 1.9-fold higher risk of AML in RA/RARS but no significant effect in other groups.

We hope these findings inform further research on inflammation-driven clonal dynamics for a large number of MDS patients with concomitant AD.”

For the article click here.
Source: Diego Adrianzen-Herrera/Twitter