Insight

Sep 2, 2024, 18:11

Kylie Walters: Finding structural motifs hidden within intrinsic disorder

Kylie Walters, Senior Investigator at National Cancer Institute, made the following post on LinkedIn:

“We applied NMR to study a linker region used in CART cell therapy to find structural motifs hidden within intrinsic disorder. This work highlights the power of NMR for studies of IDPs and insights into CART cell design. Congrats to NCI Center for Cancer Research post-baccalaureate Varvara Folimonova, Xiang Chen, Hitendra Negi, Jess Li, Charles Schwieters, and thanks to our collaborators R. Andrew Byrd, Philippe Youkharibache, Naomi Taylor!”

CD28 hinge used in chimeric antigenreceptor (CAR) T-cells exhibits localstructure and conformational exchangeamidst global disorder

Authors: Varvara Folimonova, Xiang Chen, Hitendra Negi, Charles D. Schwieters, Jess Li ,R. Andrew Byrd, Naomi Taylor, Philippe Youkharibache & Kylie J. Walters.

Source: Kylie Walters/LinkedIn

cancer CART cell Therapy Charles Schwieters Hitendra Negi intrinsic disorder Jess Li Kylie Walters Naomi Taylor National Cancer Institute NCI Center for Cancer Research NMR OncoDaily Oncology Philippe Youkharibache R. Andrew Byrd structural motifs Varvara Folimonova Xiang Chen

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