Tuomas Tammela: Co-targeting classical cells and KRAS augments response in pancreas cancer

Tuomas Tammela, Associate Member at Memorial Sloan Kettering Cancer Center, shared on X:

“New Paper! Anupriya Singh and Hannah Styers from the lab find acute resistance to targeting KRAS in pancreas cancer is surprisingly driven by a classical epithelial state.

Co-targeting classical cells and KRAS augments response – clinically important!”

Source: Tuomas Tammela/X

A classical epithelial state drives acute resistance to KRAS inhibition in pancreas

Authors: Anupriya Singhal, Hannah C. Styers, Jonathan Rub, Zhuxuan Li, Stefan R. Torborg, Jung Yun Kim, Olivera Grbovic-Huezo, Huijin Feng, Zeynep Cagla. Tarcan, Hulya Sahin Ozkan, Jill Hallin, Olca Basturk, Rona Yaeger, James G. Christensen, Doron Betel, Yan Yan, Iok In Christine Chio, Elisa de Stanchina, Tuomas Tammela