The National Cancer Institute (NCI) Toward Translation of Nanotechnology Cancer Interventions (TTNCI) R01 Grant supports advanced preclinical development of nanotechnology-based cancer diagnostics and therapeutics using engineered nanoparticles and nano-devices.
Projects should address clinically relevant unmet needs and advance promising technologies toward translational readiness, including future GMP/GLP development and NCI translational programs such as NExT. Applicants may request up to $475,000 in direct costs per year for up to four years, with the next application deadline on November 16, 2026.
Eligibility Criteria
- Eligible applicants include public and private U.S. institutions of higher education.
- Nonprofit organizations, with or without 501(c)(3) status, may apply.
- Foreign/non-U.S. organizations are not eligible to apply.
- Projects must involve advanced preclinical cancer nanotechnology research rather than early discovery-stage platform development.
- Multidisciplinary leadership is expected, with expertise spanning areas such as oncology/biology, chemistry, physics, engineering, and relevant clinical expertise.
- Clinical trials are not allowed under this R01 opportunity.
Funding Details
- Maximum direct costs: $475,000 per year.
- Maximum project duration: 4 years.
- Potential maximum direct-cost support: Up to approximately $1.9 million over four years, subject to the justified project budget.
Deadline
- Next application deadline: November 16, 2026.
- Applications are due by 5:00 PM local time of the applicant organization.
- Earliest project start: July 2027.
- Next application deadline after this cycle: May 17, 2027.
- Final listed application deadline: November 15, 2027.
- NOFO expiration: November 16, 2027.
Further Information
- Clinical trials and in vivo studies in human participants are not supported, although in vitro studies using human samples may be eligible.
- Applications must include clear annual milestones with measurable benchmarks for assessing project progress. (Grants.gov)
- Projects generating scientific data must include a Data Management and Sharing Plan, including plans for nanomaterials data sharing through caNanoLab.
- Official program page: View the NIH NOFO
- Grants.gov listing: View on Grants.gov