Long-duration funding for established researchers or teams to pursue bold, creative programmes that deliver major advances in understanding human life, health, and wellbeing. Open across disciplines and geographies (UK, Republic of Ireland, and eligible LMICs; excluding India and mainland China).
Eligibility Criteria:
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Lead applicant is an established researcher; apply as an individual (no coapplicants) or as a team led by an established researcher.
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Administering organisation: not-for-profit in the UK, Republic of Ireland, or eligible LMIC.
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Research must fit Wellcome Discovery Research remit and aim for significant shifts in understanding and/or new methods, frameworks, tools, or techniques.
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Cannot transfer funds into mainland China.
Funding Details:
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Ask for the resources you need (average ~£3.5M; >£5M faces additional scrutiny).
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Duration up to 8 years (average ~7 years; part-time possible with adjusted term).
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Covers research costs (staff, consumables, equipment, access charges, overheads, travel, open access, etc.).
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Lead applicant salary generally not included (limited exceptions for LMIC settings per guidance).
Deadline:
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Application Deadline: 25 November 2025 (15:00 GMT)
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Shortlisting: February 2026
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Interviews: 19–21 May 2026
Where To Go For Further Information: