State‐of‐the‐art P50 center grants supporting integrated translational research in organ‐specific or theme‐based cancers. Each SPORE includes at least three projects (or two large projects at renewal), an Administrative Core, a Biospecimen Core, a Developmental Research Program, a Career Enhancement Program, and at least one investigator‐initiated clinical trial.
Eligibility Criteria:
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U.S. applicant institutions (academic, nonprofit, for‐profit, or government).
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PD/PI commitment of at least 2.4 person‐months (or at least 1.8 each if three or more PD/PIs).
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Minimum of four investigators with active peer‐reviewed cancer grants or NCI trial leadership.
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New applications: at least three translational projects with human endpoints (including at least one clinical trial).
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Renewal applications: option for two large, multi‐institutional projects.
Funding Details:
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Up to USD 1.4 million direct costs per year.
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Additional USD 120 thousand per year for qualified Early Detection, Prevention, or Population Science (EPPS) projects.
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Additional USD 120 thousand per year for qualified Cancer Health Disparities/Minority Health (CHD-MH) projects.
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USD 50 thousand per year discretionary Administrative Core funds.
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Support for SPORE-related investigator travel (up to ten investigators to NCI-sponsored meetings).
Deadlines:
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Application due by 5 PM local time on September 25 2025.
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Letter of Intent due 30 days before each application deadline.
Where to Apply & Contact:
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Apply via NIH ASSIST.
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Funding Opportunity PAR-23-284.
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Program Director, NCI SPOREs: Igor Kuzmin, Ph.D. ([email protected]).