Jun 2, 2025, 08:37

The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)

U01 cooperative‐agreement projects using integrative, systems‐level approaches to address defined gaps in cancer metastasis (e.g., dormancy, early dissemination, microenvironment crosstalk). Must integrate with existing U54 MetNet Centers, share data/resources, and set aside 25K CAD/year (Years 2–5) for intra‐network pilot projects. Include a designated Resource & Data Sharing Manager.

Eligibility

Eligible entities (U.S. & foreign): colleges/universities; nonprofits; for‐profits (incl. small businesses); tribal, local/state governments; faith‐based, community, regional organizations; non‐U.S. entities.
Project type: Research only (no clinical trials), systems‐level metastasis focus, not duplicating existing MetNet work.
Investigators: Multi‐disciplinary teams encouraged; PD(s)/PI(s) must have eRA Commons accounts.

Funding

Mechanism: U01 (cooperative agreement, no clinical trials)
Direct costs: Up to $500K/year max (must include 25K CAD/year for pilot projects and travel)
Project period: Up to 5 years
Estimated awards: Depends on NIH appropriations and merit

Key Dates

Open (earliest submission): May 20, 2025
LOI due: 30 days before due date
Application due: Jun 20, 2025, 5 PM local time
Review: Nov 2025; Advisory Council: Jan 2026; Earliest start: Apr 2026
Expiration: Jun 21, 2025

Review Criteria

Significance & Innovation: Does it address a MetNet priority (e.g., dormancy, early dissemination) with novel systems‐level insight?
Rigor & Feasibility: Are designs, controls, sample sizes, and analyses robust? Can systems‐level methods be executed as proposed?
Team Expertise & Environment: Does the team combine requisite expertise (metastasis biology + systems approaches)? Is the Resource & Data Sharing Manager’s role clear?

Additional considerations: Human subject protection; animal welfare; biohazard safety; resource authentication; budget justification.

Contacts

Scientific/Research: Joanna M. Watson, Ph.D. | 240-276-6206 | [email protected]
Peer Review: Referral Officer, NCI | 240-276-6390 | [email protected]
Grants Management: Crystal Wolfrey | 240-276-6277 | [email protected]
GrantsInfo: [email protected] | 301-480-7075
Grants.gov Support: [email protected] | 800-518-4726

cancer metastasis Data Sharing dormancy early dissemination microenvironment NCI MetNet network collaboration Pilot Projects systems biology U01 cooperative agreement

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