
The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
U01 cooperative‐agreement projects using integrative, systems‐level approaches to address defined gaps in cancer metastasis (e.g., dormancy, early dissemination, microenvironment crosstalk). Must integrate with existing U54 MetNet Centers, share data/resources, and set aside 25K CAD/year (Years 2–5) for intra‐network pilot projects. Include a designated Resource & Data Sharing Manager.
Eligibility
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Eligible entities (U.S. & foreign): colleges/universities; nonprofits; for‐profits (incl. small businesses); tribal, local/state governments; faith‐based, community, regional organizations; non‐U.S. entities.
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Project type: Research only (no clinical trials), systems‐level metastasis focus, not duplicating existing MetNet work.
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Investigators: Multi‐disciplinary teams encouraged; PD(s)/PI(s) must have eRA Commons accounts.
Funding
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Mechanism: U01 (cooperative agreement, no clinical trials)
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Direct costs: Up to $500K/year max (must include 25K CAD/year for pilot projects and travel)
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Project period: Up to 5 years
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Estimated awards: Depends on NIH appropriations and merit
Key Dates
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Open (earliest submission): May 20, 2025
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LOI due: 30 days before due date
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Application due: Jun 20, 2025, 5 PM local time
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Review: Nov 2025; Advisory Council: Jan 2026; Earliest start: Apr 2026
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Expiration: Jun 21, 2025
Review Criteria
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Significance & Innovation: Does it address a MetNet priority (e.g., dormancy, early dissemination) with novel systems‐level insight?
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Rigor & Feasibility: Are designs, controls, sample sizes, and analyses robust? Can systems‐level methods be executed as proposed?
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Team Expertise & Environment: Does the team combine requisite expertise (metastasis biology + systems approaches)? Is the Resource & Data Sharing Manager’s role clear?
Additional considerations: Human subject protection; animal welfare; biohazard safety; resource authentication; budget justification.
Contacts
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Scientific/Research: Joanna M. Watson, Ph.D. | 240-276-6206 | [email protected]
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Peer Review: Referral Officer, NCI | 240-276-6390 | [email protected]
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Grants Management: Crystal Wolfrey | 240-276-6277 | [email protected]
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GrantsInfo: [email protected] | 301-480-7075
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Grants.gov Support: [email protected] | 800-518-4726
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