Jun 2, 2025, 07:59

Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed)

This U01 cooperative agreement supports fundamental, mechanistic studies to define how dietary factors influence lipid metabolism in tumors and the microenvironment, and how those lipid-mediated changes drive cancer growth and progression. Projects should bridge nutrition science and tumor biology by elucidating molecular pathways linking specific diets (e.g., high-fat, ketogenic, or nutrient-restricted regimens) to alterations in lipid uptake, synthesis, signaling, or stromal interactions that affect tumor behavior.

Eligibility Criteria

Eligible organizations: U.S. higher-education institutions (public/state‐controlled or private), nonprofits (501(c)(3) or not), for-profit entities (including small businesses), local/state/county governments, Native American tribal governments/organizations, faith-based or community organizations.
Foreign (non-U.S.) organizations are not eligible; foreign components as collaborations are allowed.
PD/PI must have expertise in both nutrition (or dietetics) and cancer biology; co-Investigator or MPI structure is strongly encouraged to ensure transdisciplinary expertise.
Applications must propose mechanistic (not descriptive) investigations of dietary variables on tumor lipid metabolism; inclusion of clinical translation aims is optional but not required.
No clinical trials or human intervention studies.

Funding Details

Application budgets: up to $500,000 direct costs per year.
Project period: up to 5 years.
Mechanism: U01 Research Project – Cooperative Agreement (substantial NIH involvement via an NCI project scientist and consortial working groups).
Expected consortium activities: annual virtual meetings, data/tool sharing, collaborative working groups.

Key Deadlines

Letter of intent (recommended): 30 days before application due date.
Application due dates (by 5:00 PM local time):
- October 23, 2025 (for earliest start July 2026)
Expiration: October 24, 2025

Cancer Metabolism diet and cancer Dietary interventions High-fat diet Ketogenic diet Lipid Metabolism Lipid signaling Mechanistic studies NCI funding Nutrition science Preclinical models tumor microenvironment tumor progression Tumor-stroma interactions U01 cooperative agreement

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