May 12, 2025, 20:04

Cancer Grand Challenge: Mechanisms Driving Mutational Signatures

This challenge aims to identify the underlying biological and chemical mechanisms responsible for unexplained mutational signatures in cancer genomes. Despite the discovery of over 96 distinct mutational signatures, many remain without known causes. Understanding the origin of these DNA alterations could reveal endogenous or environmental mutagens and pave the way for effective cancer prevention strategies.

Eligibility Criteria:

Global, interdisciplinary research teams
Expertise in areas such as chemistry, DNA repair, mutagenesis, mass spectrometry, sequencing, and epidemiology

Funding Details:

Up to £20 million (USD 25 million) per team
Duration: Not specified, but designed for major scientific breakthroughs

Deadline:

Expressions of Interest due: 18 June 2025

More Information:

Submit your Expression of Interest

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