The Mayo Clinic Multidisciplinary Head and Neck Cancer Symposium 2027 will take place on March 4–6, 2027, at the Omni Orlando Resort at ChampionsGate in ChampionsGate, Florida, United States, with livestream participation also available.

Organized by Mayo Clinic, the three-day educational meeting will bring together specialists involved in the diagnosis, treatment, and supportive care of patients with head and neck cancers.

The scientific program will explore advances in surgical oncology, radiation oncology, and systemic therapy, with sessions addressing perioperative immunotherapy, HPV-associated head and neck cancers, circulating tumor HPV DNA, and emerging approaches to treatment personalization. Case-based discussions will examine treatment decisions across oropharyngeal, oral cavity, sinonasal, nasopharyngeal, and laryngeal malignancies, including radiation de-escalation strategies and organ preservation.

The symposium will also address long-term survivorship, with discussions on swallowing and voice rehabilitation, radiation-associated complications, pain management, nutrition, and quality of life. Designed for physicians, advanced practice providers, nurses, pharmacists, dentists, rehabilitation specialists, and researchers, the meeting will encourage multidisciplinary collaboration and the practical application of current evidence in head and neck cancer care.