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Day 3 of GU24 ASCO Highlights by Oncology Brothers
Feb 2, 2024, 17:33

Day 3 of GU24 ASCO Highlights by Oncology Brothers

Oncology Brothers recently tweeted:

“Day 3 of GU24 ASCO Highlights

1. KN564: Adj Pembro w/ +ve OS

2. LITESPARK005

3. Updates in RCC:
– CM214
– CM9ER
– CLEAR
– SubC Nivo

1. KN564: Pembro was approved for high risk adj RCC in November 2021 based off this study. Today, we saw an update at 57mos with OS benefit.

– Median not reached (55 vs 86 OS events), HR: 0.62
– Pembro will/should remain the SoC in this setting.

2. LITESPARK005: Belzutifan was approved in December 2023 after PDL1/TKI based off study. At the time: Improved PFS HR: 0.75. Now, patient reported outcomes:

– QoL on both scales (FKSI and QLQ) was better with belzutifan
– Awaiting OS (was immature at the time of approval).

3. Updates for RCC:

– CM214: Ipi/Nivo combo continues to show OS benefit in intermediate and poor risk. OS has improved in favorable category over period of time.

– CM9ER: Nivo/Cabo ongoing OS benefit (46.5 most and HR: 0.77)

– CLEAR: Pembro/Len benefit in all tumor burden/sizes

– SubC Nivo ≤ 5 mins and was non-inferior to Nivo IV.”

Source: Oncology Brothers/X