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MSS Colorectal Cancer – New Immunotherapy Strategies and Metastatic Impact
Apr 3, 2025, 06:36

MSS Colorectal Cancer – New Immunotherapy Strategies and Metastatic Impact

In the inaugural event of the Global Cancer Movement, initiated by OncoDaily, Marwan Fakih explores groundbreaking research on identifying patients with microsatellite-stable (MSS) colorectal cancer (CRC) who may respond to immunotherapy, despite the absence of strong tissue biomarkers.

Key discussion points include:

  • Clinical signatures that predict immunotherapy response in MSS-CRC.
  • The role of PD-1 and CTLA-4 inhibition in improving treatment outcomes.
  • The impact of metastatic sites, with liver metastases linked to resistance.
  • Findings from key studies, including JAMA Network (2021) and LEAP-017 trials.
  • The potential of CTLA-4 inhibitors in enhancing responses in non-liver metastases.